By Tadeusz Korzybski
Antibiotics: beginning, Nature and houses, quantity I is a scientific insurance of the assets, types, and houses of the antibiotics. This booklet is geared up into major components encompassing thirteen chapters.
This publication considers the antibiotics in response to their assets. It describes the antibiotics produced by way of micro organism, Actinomycetes,Fungi imperfecti, Basidiomycetes, algae, lichens and eco-friendly vegetation, and people from animal resources. This crew of antibiotics contains, streptomycin, the tetracyclines, chloromycetin, the macrolide relations of compounds of which erythromycin, magnamycin and spiramycin are participants, and the antifungal polyene compounds. The participants of every staff are prepared in line with their chemical and organic similarity. Sections on every one antibiotic current entire info, together with the identify, description of the manufacturing traces, composition of the media, tools of tradition, isolation and purification of the antibiotic precept, its actual and chemical homes, antibiotic spectrum, toxicity for laboratory animals, result of remedy of experimental infections, and attainable medical functions.
This e-book is of worth to researchers and employees in quite a few scientific fields.
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Additional info for Antibiotics. Origin, Nature and Properties
Extracted the antibiotic from Serratia marcescens cells with acetone and after re-extracting with petroleum ether, evaporated the extract in vacuo at 3 0 - 4 0 ° C . Prodigiosin is a monovalent base, C 2 0 H 2 3 O N 3 , which in the amorphous state has the appearance of red platelets with green metaUic sheen. T h e following crystaUine salts of prodigiosin were obtained: picrate, salicylate, benzoate, hydrochloride and perchlorate. T h e latter crystallizes on addition of perchloric acid to an ethanolic solution of prodigiosin hydrochloride.
When acetic acid was added to the medium, both carbon atoms, the one of the carboxyl group and the one of the methyl group, are utihzed in biosynthesis. T h e isotope from D L - l e u c i n e or a m m o n i u m salts containing ^^N was not incorporated into prodigiosin, but was recovered in the proteins of the bacterial cells. Santer and Vogel found that one of two mutants of the strain Serratia marcescens, mutant 9 - 3 - 3 , produces a substance, C10H10O2N2, which has been isolated, and found to have a composition of C , 63-0; H , 5-3; O, 17-0; N , 14-7; CH3O, 16-6%.
C o u n t e r - c u r r e n t distribution of nisin. Nature, B E R R I D G E N. : Chemistry B E R R I D G E N . , N E W T ON nisin. Biochem. , and Industry, G. G. F. and 1952, 52, 529. 1947, N o . 2, 7. 1949, 4 5 , 486. 1952, 169, 707. 1953, 374. A B R A H A M E . : Purification a n d n a t u r e of the antibiotic 30 ANTIBIOTICS J. , G O W A NS S M I TH N . and F L O R EY W . : S o m e p r o p e r t i e s of nisin. Brit. J. Pharm, and H. , 1 9 5 2 , 7, 4 3 8 . : J. Gen. Microbiol, 1950, 4, 70.