Aulton's Pharmaceutics: The Design and Manufacture of by Michael E. Aulton BPharm PhD FAAPS FSP FRPharmS, Kevin

By Michael E. Aulton BPharm PhD FAAPS FSP FRPharmS, Kevin M.G. Taylor BPharm PhD FAAPS FRPharmS

Pharmaceutics is among the such a lot various topic components in all of pharmaceutical technological know-how. in short, it really is inquisitive about the medical and technological elements of the layout and manufacture of dosage types or medications. An realizing of pharmaceutics is accordingly important for all pharmacists and people pharmaceutical scientists who're concerned with changing a drug or a possible drug right into a medication that may be brought effectively, successfully and very easily to the patient.

Now in its fourth version, this best-selling textbook in pharmaceutics has been introduced thoroughly modern to mirror the quick advances in supply methodologies via eye and injection, advances in drug formulations and supply tools for targeted teams (such as kids and the elderly), nanomedicine, and pharmacognosy. whilst the editors have striven to take care of the accessibility of the textual content for college students of pharmacy, maintaining the stability among being a definitely pitched introductory textual content and a transparent mirrored image of the country of the art.

provides a logical, finished account of drug layout and manufacture
includes the technological know-how of formula and drug delivery
designed and written for newbies to the layout of dosage forms
New to this edition
New editor: Kevin Taylor, Professor of medical Pharmaceutics, university of Pharmacy, college of London.
Twenty-two new contributors.
Six new chapters protecting parenteral and ocular supply; layout and management of medications for the youngsters and aged; the most recent in plant medicinal drugs; nanotechnology and nanomedicines, and the supply of biopharmaceuticals.
Thoroughly revised and up to date all through.

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Additional resources for Aulton's Pharmaceutics: The Design and Manufacture of Medicines

Example text

The equation reveals that dissolution rate can be raised by increasing the surface area (reducing particle size) of the drug, by increasing the solubility of the drug in the diffusion layer and by increasing k which in this equation incorporates the drug diffusion coefcient and the diffusion layer thickness. During the early phases of dissolution, C S > C and if the surface area, A, and experimental conditions are kept constant then k can be determined for compacts containing drug alone. The constant k is termed the intrinsic dissolution rate constant and is a characteristic of each solid drug compound in a given solvent under xed hydrodynamic conditions.

G. H ansen parameters and interaction parameters. These have improved the quantitative treatment of systems in which polar effects and interactions occur. g. dielectric constant and dipole moment, have often been linked by empirical or semi-empirical relationships either to these parameters or to solvent properties. Studies on solubility parameters are reported in the pharmaceutical literature. The use of dielectric constants as indicators of solvent power has also received attention but deviations from the behaviour predicted by such methods may occur in practice.

To rationalize the above rules, you can consider the forces of attraction between solute and solvent molecules. The following explains the basic physicochemical properties of solutions that lead to such observations. s olub ility Similar types of intermolecular force may contribute to solute–solvent, solute–solute and solvent– solvent interactions. The attractive forces exerted between polar molecules are much stronger, however, than those that exist between polar and non-polar molecules or between non-polar molecules themselves.

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