Clin-alert 2001 : a quick reference to adverse clinical by Joyce Generali

By Joyce Generali

Provides a compilation of abstracts from the former year's Clin-Alert e-newsletter, which collects, summarizes and studies newly released information about major adversarial drug results and drug interactions. The abstracts are prepared alphabetically inside of each one drug category. assurance extends to substitute medications and natural remedies. Sep.

summary: offers a compilation of abstracts from the former year's Clin-Alert publication, which collects, summarizes and stories newly released information about major antagonistic drug results and drug interactions. The abstracts are prepared alphabetically inside each one drug type. insurance extends to substitute drugs and natural cures. Sep

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Extra resources for Clin-alert 2001 : a quick reference to adverse clinical events

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Abdominal pain, vomiting, diarrhea) were absent. Screening tests for infectious etiologies or gastrointestinal bleeding were also negative. The red stools resolved after another antibiotic was substituted for cefdinir. No time frame for symptom resolution was provided. Patient 2: A five-month-old outpatient developed red stools within 24 hours after starting cefdinir for an otitis media infection, which was refractory to several previous antibiotic regimens. Dosage information was not provided.

The authors concluded that the appearance and resolution of symptoms was temporally related to levofloxacin administration. They also noted that this patient had underlying atrial fibrillation, which may have been a predisposition for ventricular tachycardia. Samaha FF (Univ Pennsylvania Med Center & Philadelphia Dept of VA Med Center Philadelphia, PA) QTc interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin. Am J Med 107528-529 (Nov) 1999 (letter) TROVAFLOXACIN Neurotoxicity Three case reports describe the development of neurotoxicity associated with short-term use of trovafloxacin in adult patients.

Symptoms improved with bronchodilators, corticosteroids and antibiotics with patient discharge after three days of hospitalization. The authors concluded that respiratory distress was associated with zanamivir use in this patient. Although an exact mechanism of action was not provided, the authors noted that manufacturer guidelines for zanamivir recommend that the drug be stopped if bronchospasm occurs or respiratory function deteriorates after drug use. In addition, patients with underlying lung disease should have ready access to inhaled bronchodilators if needed.

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