Cyclic Nucleotide Phosphodiesterases in Health and Disease by Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay

By Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay

Because the final significant compendium devoted to cyclic nucleotide phosphodiesterases (PDEs) was once released over 15 years in the past, a tremendous volume of growth has happened within the box. there's nice desire for a centralized resource for key details during this burgeoning and therapeutically very important sector of scientific examine.

Cyclic Nucleotide Phosphodiesterases in future health and sickness offers an built-in quantity masking PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological pursuits in addition to the advance of particular PDE inhibitors as healing brokers. With contributions from pioneers within the box, person chapters describe one of many eleven recognized mammalian PDE households together with the molecular features, constitution, functionality, and qualities specific to every. features of PDEs from reduce organisms also are the topic of different chapters considering the fact that they supply key insights into PDE capabilities and also are pharmacological pursuits for therapy of quite a few ailments in people and household animals. Chapters at the present biomedical and healing learn on PDEs comprise reviews on gene-targeted knockout innovations and compartmentation in cyclic nucleotide signaling. via unraveling the original mobile roles for various PDEs, scientists are commencing to open the door to the healing use of PDE inhibitors for the remedy of a few pathological stipulations together with bronchial asthma and irritation, pulmonary high blood pressure, erectile disorder, and stroke.

By collating present details right into a coherent and coordinated viewpoint, Cyclic Nucleotide Phosphodiesterases in health and wellbeing and illness offers a useful reference for and scientific scientists and issues towards destiny instructions of analysis and healing developments in constructing selective inhibitors for those quite a few enzymes.

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Loughney. 1999. Isolation, expression and analysis of splice variants of a human Ca2þ=calmodulin-stimulated phosphodiesterase (PDE1A). Cell Signal 11:535–544. 3. D. E. S. G. A. Beavo. 1998. Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases. Methods 14:3–19. 4. , D. S. Kwak, J. Huang, H. A. Beavo. 1995. Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases.

J. S. A. Giembycz. 2004. Discovery of BRL 50481 [3-(N,N -dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages, and CD8þ T-lymphocytes. Mol Pharmacol 66 (6):1679–89. 34. , S. Wolda, E. Moon, J. Esselstyn, C. Hertel, and A. Lerner. 2002. PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP. Cell Signal 14 (3):277–84. 35. , A. Tersteegen, A. Rebmann, C. Erb, T. Fahrig, and M.

Michibata, T. Sasaki, and K. Omori. 2000. Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression. J Biol Chem 275:31469–31479. 106. , Kineaid. 1992. Molecular clearing of DNA encoding a calmodulin-dependent phospho diesterase enriched in striatum. Proc. Natl. Acad. Sci. USA. 89:11079–11083. 2006 11:31am Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases Andrew T. 2 Introduction ................................................................................................................

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