DHEA and the brain by Morfin, Robert

By Morfin, Robert

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Of the more than 200 known strains of rat, the following five are most frequently used in research: Fischer 344, Sprague-Dawley, Long-Evans, Wistar, and Brown Norway (Weindruch and Masoro, 1991; van der Staay, 2000). Experiments have demonstrated that along with age, sex, and health status, strain differences can affect physiological and behavioral parameters. [For a review see Kacew et al. ] The use of inbred strains limits genetic variability but can introduce strainrelated differences in performance, in response to treatments, and in vulnerability to pathologies.

2 EXPLORATORY ACTIVITY Measurement of exploratory behavior can take place in a variety of environments. [For reviews see Alleva and Sorace (2000) and Kelley et al. ] Most commonly used is the open field. For rats, this is a 1 m2 white open box with the floor marked by a grid dividing the region into inner and outer units. Animals are placed individually into the open field and their movement (unit crossings), rearings, and time spent grooming and being inactive are measured either manually or by a computer-assisted image analysis system for a time period of 2 to 30 min.

B. (1999) The effects of paradoxical sleep deprivation and valine on spatial learning and brain 5-HT metabolism. Physiology & Behavior, 67, 643–649. , Xiu, R. (2000) The therapeutic effect of Ginkgo biloba extract in shr rats and its possible mechanisms based on cerebral microvascular flow and vasomotion. Clinical Hemorheology and Microcirculation, 23, 133–138. R. (2001) Alphalipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the AKT signalling pathway.

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