Drug Discovery from Mother Nature by Subash Chandra Gupta, Sahdeo Prasad, Bharat B. Aggarwal

By Subash Chandra Gupta, Sahdeo Prasad, Bharat B. Aggarwal

Second entire quantity specializes in anti inflammatory nutraceuticals and their position in prevention and treatment of assorted power ailments. meals and drug management (FDA) authorized medications corresponding to steroids, non-steroidal anti inflammatory medicinal drugs (NSAIDS), statins and metformin were proven to modulate inflammatory pathways, yet their long term consumption has been linked to a variety of uncomfortable side effects. therefore nutritional brokers that could modulate inflammatory pathways in people, are inclined to convey huge, immense power. best specialists describe the most recent result of anti inflammatory nutraceuticals and their function in prevention and remedy of assorted persistent diseases.

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Kreeman V, Skottova N, Walterova D (1998) Silymarin inhibits the development of diet-induced hypercholesterolemia in rats. Planta Med 64:138–142 49. Gazak R, Walterova D, Kren V (2007) Silybin and silymarin—new and emerging applications in medicine. Curr Med Chem 14:315–338 50. Tyagi A, Agarwal C, Harrison G et al (2004) Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis 25:1711–1720 51.

Silymarin has been reported to induced and augmented human cervical cancer cell apoptosis through p38/JNK MAPKs [45]. • Prostate cancer Silymarin acts as anti-proliferative, pro-apoptotic, and anti-angiogenic in prostate tumor. It inhibits the growth of prostate cancer cells both in vitro and in vivo. Silymarin also modulates MAPK, ERK 1/2, and IGF signaling pathways [46]. Silymarin and Its Role in Chronic Diseases 33 • Skin cancer Skin cancers occur due to ultraviolet light-induced immunosuppression and oxidative stress.

Many reports also indicate that silymarin increases the binding of b-TrCP to phosphorylated b-catenin which results in degradation or inactivation of b-catenin [23]. 5. Modulation of EGFR-MAPK/ERK1/2/AKT/mTOR/PP2A signaling It has been evidenced that silymarin treatment inhibits transforming growth factor a-mediated activation of erbB1 in human prostate carcinoma cells. Along with this, it also inhibits the tyrosine phosphorylation of an adaptor protein Shc which is the immediate downstream target erbB1 [24].

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